You may get drowsy or dizzy. Don't generate, use machinery, or do everything that demands mental alertness until eventually you know how this medication influences you.
Owing to generous benefactors, your gift right now might have 5X the impression to progress AI innovation at Mayo Clinic.
Get medical enable instantly Should you have any quite significant Unwanted effects, which include: slow/shallow respiration, seizures.
Promethazine is contraindicated in comatose states, As well as in persons known to get hypersensitive or to own had an idiosyncratic reaction to promethazine or to other phenothiazines.
Promethazine hydrochloride and codeine phosphate need to be specified to some pregnant lady only if Plainly necessary.
The diagnostic evaluation of clients with this particular syndrome is difficult. In arriving in a diagnosis, it's important to establish cases where the medical presentation includes the two severe health care sickness (e.
Elevated strain within your head (elevated intracranial force). Stay clear of the usage of Promethazine Hydrochloride and Codeine Phosphate Oral Resolution For those who have a head injuries or are already informed that you've got improvements from the tissue of one's brain (brain lesions) or increased pressure in the head.
Codeine In an embryofetal improvement examine in pregnant rats dosed throughout the duration of organogenesis, codeine greater resorptions and diminished fetal weights at a dose about twenty five times the MRHD (over a mg/m2 basis by using a maternal oral dose of 120 mg/kg/day); on the other hand, these outcomes happened during the presence of maternal toxicity.
Unique experiments to check the motion from the drug on parturition, lactation, and enhancement from the animal neonate were not completed, but a common preliminary examine in rats indicated no effect on these parameters.
To give you probably the most relevant and beneficial facts, and comprehend which information and facts is helpful, we could Mix your e-mail and website use information and facts with other data Now we have Promethazine codeine syrup about you. When you are a Mayo Clinic affected person, This may incorporate guarded health and fitness information and facts.
Significant, existence-threatening, or lethal respiratory melancholy has long been noted with the usage of opioids, such as codeine, on the list of Energetic elements in Promethazine HCl and Codeine Phosphate Oral Solution. Codeine produces dose-related respiratory melancholy by directly performing over the Mind stem respiratory center that controls respiratory rhythm and could generate irregular and periodic breathing. Codeine is subject matter to variability in metabolism based upon CYP2D6 genotype, which may result in a heightened publicity for the Lively metabolite morphine [see Warnings and Precautions (five.three)]. Promethazine exerts a depressant effect on the respiratory Middle that is certainly unbiased of and additive to that of other respiratory depressants, which includes codeine [see Warnings and Safety measures (five.
Having said that, this outcome will not be constant and will be offset by an elevated price of cervical dilation, which tends to shorten labor. Watch neonates subjected to opioids in the course of labor for signs of excessive sedation and respiratory depression.
Opioid analgesics and antitussives, which include codeine, among the list of active components in Promethazine HCl and Codeine Phosphate Oral Alternative, shouldn't be used in patients with acute febrile health issues linked to successful cough or in patients with Persistent respiratory illness exactly where interference with power to distinct the tracheobronchial tree of secretions would have a deleterious effect on the patient’s respiratory functionality.
Notify your physician In the event your cough will not recuperate in 5 days. Also, convey to your medical doctor Should your situation will get even worse, or For those who have a headache that does not go away, fever, or rash. These can be indicators of a serious healthcare trouble and may be checked by a doctor.